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Magic mushrooms have the potential to be an effective antidepressant, according to new research.

Psilocybin – the active ingredient in magic mushrooms – has shown promise in reducing symptoms of depression after one or two doses, with few side effects and no signs of causing addiction.

But past studies have not investigated things that might influence how effective the psychedelic is, such as the dose, whether people have taken psychedelics before and the type of depression.

Researchers set out to address this by looking at randomised controlled trials that compared psilocybin with control substances such as a placebo, vitamin B or micro-dosing psychedelics.

Their research was published in medical journal the BMJ.

They looked at seven trials involving 436 people with depression. The change in their depression was measured using a system called “Hedges’ g”.

A score of 0.2 indicates a small effect, 0.5 a moderate effect, and 0.8 or more a large effect.

Overall people treated with psilocybin recorded a score of 1.64.

Greater improvements were seen in older people, those who had used psychedelics before and people with secondary depression (related to an underlying disease) rather than primary depression.

The researchers said the findings are encouraging but further research is needed “to clarify the factors that maximise psilocybin’s treatment potential for symptoms of depression”.

They said issues such as cost, lack of regulatory guidelines and legal safeguards associated with psilocybin treatment need to be dealt with before it can be established in clinical practice.

Read more:
Mums on magic mushrooms: Why parents are ‘microdosing’
Magic mushrooms ‘could help with cancer-related depression’

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Consultant psychiatrist Dr Paul Keedwell called the results “impressive”, noting the rapid improvement for many patients.

“Longer follow ups would be welcome, and there is more work to be done on optimal dosing,” he said.

“It seems that a strong psychedelic experience is needed to get the best results.

“The main disadvantage is that some patients find the psychedelic effects unpleasant, and care must be taken to ensure a calm environment for the treatment.”

The authors note that as their analysis uses data drawn from different studies, it is not possible to differentiate between people most likely to benefit from psilocybin and those who might instead experience adverse effects.

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<p> India's manufacturing sector stays strong despite slight dip in April PMI to 58.8</p>
India’s manufacturing sector stays strong despite slight dip in April PMI to 58.8

India’s manufacturing sector experienced a slight deceleration in growth in April, yet remained robust due to sustained high demand, according to data released by a private business survey on Thursday.

The HSBC final India Manufacturing Purchasing Managers’ Index (PMI) moderated to 58.8 in April from a 16-year high of 59.1 in March. Despite this dip, India’s PMI has consistently remained above the neutral mark of 50.0 and its long-run average of 53.9, indicating continued expansion in the sector.

Pranjul Bhandari, Chief India Economist at HSBC, noted, “April’s manufacturing PMI recorded the second-fastest improvement in operating conditions in three-and-a-half years, bolstered by strong demand conditions which resulted in a further expansion of output, albeit slightly slower than in March.”

The report highlighted a surge in input stocks to levels unseen in the past 19 years, showcasing manufacturers’ confidence in future demand. Additionally, increased buying levels, coupled with improved supplier performance, facilitated inventory-building initiatives.

Bhandari further elaborated, “Improvements in suppliers’ delivery times contributed to increased purchasing activity. Additionally, a positive outlook for the year ahead prompted firms to expand their staffing levels.”

One notable aspect of April’s performance was the remarkable rise in raw material stocks, reaching their highest point since June 2023. Despite escalating costs of raw materials and labor, inflation remained below historical averages, prompting manufacturers to pass on these increases to consumers through higher output charges, thereby bolstering margins.

“On the price front, higher costs of raw materials and labour led to a modest uptick in input costs, but inflation remains below the historical average. However, firms passed these increases onto consumers through higher output charges, as demand remained resilient, resulting in improved margins,” Bhandari said.

Sustained improvements in demand, both domestically and internationally, were cited as key growth drivers, with new export orders witnessing a notable increase. Manufacturers foresee a positive outlook for the year ahead, with expectations of higher output and buoyant demand, further supported by strengthening business confidence.

In response to the surge in demand, manufacturers expanded their workforce at the quickest pace since September 2023. Despite intensifying cost pressures, the sector remained resilient, with inflationary pressures below long-run averages.

Amid reports of rising material and labor costs, Indian manufacturers remained optimistic about the future outlook, viewing advertising and brand recognition as opportunities for further growth, the report concluded.

  • Published On May 2, 2024 at 11:13 AM IST

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